Sugeng Riyanto .drg

Sugeng Riyanto .drg

Boy M Bachtiar

Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia

 

 

 

 

 

Abstract:

Periodontal disease is a pathological condition that involves inflammation process induced by mature subgingival plaque, which means un-controlled biofilm has occurred. This is a key point in clinical consideration when using antibiotic as adjunct in periodontal therapy as biofilm disruption is a necessary step. This is due to undisrupted biofilm may decrease the efficacy of antimicrobial therapy.  Periodontopathogens that consistently associated with periodontal disease are the red complex (P. gingivalis, T. forsythia, and P. Intermedia).  As Gram-negative bacteria, their cell wall consists of lipopolysaccharides that act as powerful stimulants for inflammatory reaction. Thus, the presence of these bacteria is a marker for destructive periodontal disease.  The host defense system, including innate and adaptive immunity, is another determinant in the pathogenesis of periodontal disease. The initial inflammation in the periodontal tissues is a physiologic defense mechanism triggered by the microbial in biofilm. Thus, it is not pathology reaction. Failure to eradicate the biofilms, especially  in sub-gingival  pocket, the established lesion exist that reflects a pathology stage. This is also a period of transition from the innate to the acquired immune response.  At this time, inflammatory cells such as macrophages, plasma cells, and T and B lymphocytes are dominant and will continue to produce inflammatory mediators in an effort to destroy the pathogens. Finally, researchers have found that genetic signaling pathways is the other determinant that affects individual response by influence the expression of inflammatory mediators in response to the presence of periodontopathogen.

Hall PJ et al. Presented at the General Session and Exhibition of the Pan European Federation of the International Association for Dental Research (PEF IADR) 2008, September 10−12. London, England. Poster 466.

 

Purpose/objective          

To compare the dispersion of Sensodyne iso-active™ compared with a regular marketed 5% potassium nitrate toothpaste, by measuring the post-brushing potassium levels recovered in the:

  • expectorated slurry
  • post-brush rinse
  • toothbrush head 

 

Please download journal from attachment below

Gross RC et al. Presented at the General Session and Exhibition of the Pan European Federation of the International Association for Dental Research (PEF IADR) 2008, September 10−12. London, England. Poster 467.

 

Purpose/objective      To compare Sensodyne iso-active™ to a standard toothpaste (Elmex Sensitive) and a standard gel (Colgate Total) after a single brushing period for:

  • Foam volume generation
  • Removal of oral debris and anaerobic and volatile sulphur compound (VSC)-producing bacteria

Design and methodology     Number of subjects: 36 subjects with good general oral and physical health.

 

Please download journal from attachment below

Axelrod S and Minkoff S. 1981. GSK data on file

Purpose/objective

• To evaluate the efficacy of two potassium nitrate (KNO3) toothpastes without fluoride versus placebo in relieving the symptoms of dentinal hypersensitivity when used daily as an at-home  treatment

Plaque removal efficacy of four dentifrices in a single brushing model

Akwagyriam I et al. Presented at the International Association for Dental Research (IADR) 2013 General Session, March 20–23, Seattle, USA. Poster 3328.

To compare the plaque removal efficacy of a 67% sodium bicarbonate toothpaste containing herbs with that of a 0% sodium bicarbonate toothpaste following a single timed brushing (primary aim)

Aims

  • To evaluate the efficacy of parodontax® vs. a calcium carbonate placebo
  • To investigate the following parameters, assessed at baseline and after 3-months and 6-months of twice daily, unsupervised home brushing:

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